Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

Immunotherapy and immune checkpoint blocking antibodies such as anti-PD-1 are
approved and significantly improve the survival of advanced non-small cell lung cancer …

Across mammalian species, solute exchange takes place in complex microvascular
networks. In the human placenta, the primary exchange units are terminal villi that contain …

Unlike the blood, the interstitial fluid and the deriving lymph are directly bathing the cellular
layer of each organ. As such, composition analysis of the lymphatic fluid can provide more …

Lymph nodes (LN) are crucial for immune function, and comprise an important interface
between the blood and lymphatic systems. Blood vessels (BV) in LN are highly specialized …

Background: Metastatic tumor cells spread through lymphatic vessels and colonize draining
lymph nodes (LNs). It is known that tumors induce lymphangiogenesis to enhance lymphatic …

Metastatic lymph nodes (LN s) may be the origin of systemic metastases. It will be important
to develop a strategy that prevents systemic metastasis by treating these LN s at an early …

Abstract Objective Using primary LMCs in vitro, we sought to characterize the impact of LMC
remodeling on their functional and molecular response to mechanical loading and culture …

Integral representations for the velocity and pressure fields are constructed in the problem
on a three-dimensional filtration flow of a viscous fluid obeying the Darcy-Brinkman law in a …