Intravital fluorescence microscopy (IVM) is a powerful technique for imaging multiple organs,
including the brain of living mice and rats. It enables the direct visualisation of cells in situ …

As the organ of highest metabolic demand, utilizing over 25% of total body glucose
utilization via an enormous vasculature with one capillary every 73 μm, the brain evolves a …

An elevated level of homocysteine (Hcy) leads to hyperhomocysteinemia (HHcy), which
results in vascular dysfunction and pathological conditions identical to stroke symptoms. Hcy …

Vascular pathology is central to malaria pathogenesis and associated with severity of
disease. We have previously documented shedding of the cerebral endothelial glycocalyx in …

Malaria is a causative factor in about 500.000 deaths each year world-wide. Cerebral
malaria is a particularly severe complication of this disease and thus associated with an …

Background: Plasmodium falciparum, the etiologic agent of malaria, is a major cause of
infant death in Africa. Although research on the contact system has been revitalized by …

Background and Purpose—Stroke is a leading cause of disability worldwide, mainly
affecting the elderly. However, preclinical studies in aged ischemic animals are limited. N …

Malaria is an infectious disease of major worldwide clinical importance that causes a variety
of severe, or complicated, syndromes including cerebral malaria, which is often fatal …

The blood-brain barrier (BBB) regulates the transport of molecules from the blood into the
brain parenchyma. It is comprised of highly specialized brain microvascular endothelial …

Cerebral malaria is one of the most severe complications of Plasmodium falciparum
infection and occurs mostly in young African children. This syndrome results from a …