Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine
administration during resuscitation; however, prospective data to support this assertion are …

Background: Administering antimicrobial agents before obtaining blood cultures could
potentially decrease time to treatment and improve outcomes, but it is unclear how this …

Rationale: Administration of intravenous crystalloid solutions is a fundamental therapy for
sepsis, but the effect of crystalloid composition on patient outcomes remains unknown …

Sepsis is a life-threatening condition caused by infection and represents a substantial global
health burden. Recent epidemiological studies showed that sepsis mortality rates have …

Sepsis and septic shock are major causes of mortality during chemotherapy-induced
neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting …

Importance Beginning in 2013, New York State implemented regulations mandating that
hospitals implement evidence-based protocols for sepsis management, as well as report …

Among critically ill adults, sepsis remains both common and lethal. In addition to antibiotics
and source control, fluid resuscitation is a fundamental sepsis therapy. The physiology of …

Purpose We performed an individual patient data meta-analysis to investigate the possible
benefits and harms of vasopressin therapy in adults with septic shock both overall and in pre …