Pancreatic ductal adenocarcinoma (PDA) was responsible for~ 44,000 deaths in the United
States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically …

Background To describe the peripheral retinal findings associated with systemic medication
toxicity and to outline the importance of ultra-widefield imaging in the detection, analysis and …

Hydroxychloroquine (HCQ), a toll like receptor (TLR) 7 and 9 antagonist, is used during
pregnancy for inflammatory conditions with limited understanding of its placental toxicology …

Purpose Cardiotoxicity is a well-known side effect of chloroquine. Several studies have
proposed chloroquine as a potential anti-diabetic treatment but do not address this problem …

Autophagy is a homeostatic process that recycles damaged organelles and long-lived
proteins by delivering them in double-membrane vesicles to lysosomes for degradation …

Multiple myeloma (MM) is an incurable hematological malignancy driven by several genetic
and epigenetic alterations. The hyperactivation of the Polycomb repressive complex 2 …

Background Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic
diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is …

Objectives: Inhalation of crystalline silica (cSiO2) remains a significant occupational hazard
and may lead to the development of silicosis. When cSiO2 particles are phagocytized by …

A novel dual-mode nanoprobe (Apt@ MNPS) was created for the detection of autophagy-
related miRNAs to monitor the autophagic level and study the effect of PTT on autophagy …

Objectives This study aims to report our experience with photosensitive autoimmune
diseases including lupus erythematosus and dermatomyositis (DM) treated with quinacrine …