Acellular and cellular approaches to improve diabetic wound healing

H Cho, MR Blatchley, EJ Duh, S Gerecht - Advanced drug delivery reviews, 2019 - Elsevier
Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

X Bian, K Ma, C Zhang, X Fu - Stem cell research & therapy, 2019 - Springer
Ischemic diseases, which are caused by a reduction of blood supply that results in reduced
oxygen transfer and nutrient uptake, are becoming the leading cause of disabilities and …

Type 2 diabetes is associated with the accumulation of senescent T cells

EYM Lau, EC Carroll, LA Callender… - Clinical & …, 2019 - academic.oup.com
Type 2 diabetes is a global health priority, given that it is driven, in part, by an ageing
population, the role of immune senescence has been overlooked. This is surprising, as the …

Mesenchymal stem cells in homeostasis and systemic diseases: hypothesis, evidences, and therapeutic opportunities

FJ Vizoso, N Eiro, L Costa, P Esparza… - International journal of …, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known
function in tissue regeneration. However, there is also evidence indicating a broader role of …

Impaired bone regenerative effect of exosomes derived from bone marrow mesenchymal stem cells in type 1 diabetes

Y Zhu, Y Jia, Y Wang, J Xu, Y Chai - Stem Cells Translational …, 2019 - academic.oup.com
Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …

The use of fat grafting and platelet‐rich plasma for wound healing: A review of the current evidence

OJ Smith, G Jell, A Mosahebi - International Wound Journal, 2019 - Wiley Online Library
Fat grafting is becoming a common procedure in regenerative medicine because of its high
content of growth factors and adipose derived stem cells (ADSCs) and the ease of harvest …

Mesenchymal stem cell dysfunction in diabetes

A Fijany, LR Sayadi, N Khoshab, DA Banyard… - Molecular biology …, 2019 - Springer
Diabetes mellitus (DM) is a chronic disease that results in a variety of systemic
complications. Recently, stem cell-based therapies have been proposed as potential …

Impact of diabetes mellitus on human mesenchymal stromal cell biology and functionality: implications for autologous transplantation

M Mahmoud, N Abu-Shahba, O Azmy… - Stem cell reviews and …, 2019 - Springer
Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and
immunomodulatory properties to restore and repair injured tissues, making them attractive …

Heterogeneity in adipose stem cells

EA Prieto González - Stem Cells Heterogeneity-Novel Concepts, 2019 - Springer
Adipose stem cells (ASCs) are the basis of procedures intended for tissue regeneration.
These cells are heterogeneous, owing to various factors, including the donor age, sex, body …

Diabetic human adipose-derived stem cells accelerate pressure ulcer healing by inducing angiogenesis and neurogenesis

S Xiao, Z Liu, Y Yao, ZR Wei, D Wang… - Stem Cells and …, 2019 - liebertpub.com
Adipose-derived stem cells (ASCs) possess a well-characterized capacity to enhance
cutaneous wound healing. However, many controversies exist regarding ASCs from diabetic …