Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Preclinical studies in immature and adult rodents and clinical observations show that
neuroinflammation and oxidative stress are rapid onset phenomena occurring in the brain …

Febrile infection–related epilepsy syndrome (FIRES) is a severe epileptic encephalopathy
with presumed inflammatory origin and lacking effective treatments. Anakinra is the human …

Purpose Rescue medications for status epilepticus (SE) have a relatively high rate of failure.
The purpose of this review is to summarize the evidence for the efficacy of novel drugs and …

Antiepileptic drugs (AEDs) are the primary agents prescribed for clinical management of
limbic epilepsy. However, high incidence of pharmacoresistance and a limited armory of …