The advent of large-scale microbiome studies affords newfound analytical opportunities to
understand how these communities of microbes operate and relate to their environment …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …

Single-cell transcriptomics is a versatile tool for exploring heterogeneous cell populations,
but as with all genomics experiments, batch effects can hamper data integration and …

Motivation Most genomes contain thousands of genes, but for most functional responses,
only a subset of those genes are relevant. To facilitate many single-cell RNASeq …

In the interphase of the cell cycle, chromatin is arranged in a hierarchical structure within the
nucleus,, which has an important role in regulating gene expression,,–. However, the …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …

Concerted examination of multiple collections of single-cell RNA sequencing (RNA-seq)
data promises further biological insights that cannot be uncovered with individual datasets …