Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …

During viral and bacterial infections, the innate immune system recognizes various types of
pathogen-associated molecular patterns (PAMPs), such as nucleic acids, via a series of …

Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular
deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on …

SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …

Innate immunity, the first line of defense against invading pathogens, is an ancient form of
host defense found in all animals, from sponges to humans. During infection, innate immune …

ABSTRACT Approximately 4.4% of the human genome is comprised of endogenous
retroviral sequences, a record of an evolutionary battle between man and retroviruses. Much …

A review of innovative tools for creative nucleic acid chemists that open the door to novel
probes and therapeutic agents Nucleic acids continue to gain importance as novel …

The deoxynucleotide triphosphate (dNTP) hydrolase SAMHD1 inhibits retroviruses in non-
dividing myeloid cells. Although antiviral activity towards DNA viruses has also been …

Well-developed mouse models are important for understanding the pathogenesis and
progression of immunological response to viral infections in humans. Moreover, to test …

Singleton-Merten syndrome (SMS) is a type I interferonopathy characterized by dental
dysplasia, aortic calcification, skeletal abnormalities, glaucoma, and psoriasis. A missense …