Oxidative stress in cardiovascular diseases: still a therapeutic target?

T Senoner, W Dichtl - Nutrients, 2019 - mdpi.com
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

The proteostasis network and its decline in ageing

MS Hipp, P Kasturi, FU Hartl - Nature reviews Molecular cell biology, 2019 - nature.com
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

A Cuadrado, AI Rojo, G Wells, JD Hayes… - Nature reviews Drug …, 2019 - nature.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Antioxidant defence systems and oxidative stress in poultry biology: An update

PF Surai, II Kochish, VI Fisinin, MT Kidd - Antioxidants, 2019 - mdpi.com
Poultry in commercial settings are exposed to a range of stressors. A growing body of
information clearly indicates that excess ROS/RNS production and oxidative stress are …

Oxidative stress and advanced lipoxidation and glycation end products (ALEs and AGEs) in aging and age‐related diseases

NT Moldogazieva, IM Mokhosoev… - Oxidative medicine …, 2019 - Wiley Online Library
Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living
organisms and is denoted as a persistent condition of an imbalance between the generation …

Detection, identification, and quantification of oxidative protein modifications

CL Hawkins, MJ Davies - Journal of Biological Chemistry, 2019 - ASBMB
Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway

BI Arioz, B Tastan, E Tarakcioglu, KU Tufekci… - Frontiers in …, 2019 - frontiersin.org
Inflammation is a crucial component of various stress-induced responses that contributes to
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …

The chemical basis of ferroptosis

M Conrad, DA Pratt - Nature chemical biology, 2019 - nature.com
Lipid peroxidation underlies the mechanism of oxidative cell death now known as
ferroptosis. This modality, distinct from other forms of cell death, has been intensely …

[HTML][HTML] Iron homeostasis and oxidative stress: An intimate relationship

D Galaris, A Barbouti, K Pantopoulos - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Plasma medicine: A field of applied redox biology

T Von Woedtke, A Schmidt, S Bekeschus, K Wende… - In vivo, 2019 - iv.iiarjournals.org
Plasma medicine comprises the application of physical plasma directly on or in the human
body for therapeutic purposes. Three most important basic plasma effects are relevant for …