Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

The aging population is rapidly increasing all over the world. This results in significant
implications for the planning and provision of health and social care. Aging is physiologically …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one …

Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways.
Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint …

Although numerous long noncoding RNAs (lncRNAs) have been identified, our
understanding of their roles in mammalian physiology remains limited. Here, we …

Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …

In our aging society, age-related hearing loss (ARHL) has become a major socioeconomic
issue. Reactive oxygen species (ROS) may be one of the main causal factors of age-related …

The production of gametes (sperm and eggs in mammals) involves two sequential cell
divisions, meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate to …

Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue
homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and …