Adoptive cell transfer (ACT) using chimeric antigen receptor (CAR)‐modified T cells can
induce durable remissions in patients with refractory B‐lymphoid cancers. By contrast …

Over the past three decades, a considerable body of evidence has highlighted T cells as
pivotal culprits in the pathogenesis of psoriasis. This includes the association of psoriasis …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology
that primarily affects women of childbearing age. The development of SLE is attributed to the …

The evolution of the major histocompatibility complex (MHC) is shaped by frequent gene
duplications and deletions, which generate extensive variation in the number of loci (gene …

To perform detailed fine-mapping of the major-histocompatibility-complex region, we
conducted next-generation sequencing (NGS)-based typing of the 33 human leukocyte …

The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however,
increased and persistent intestinal inflammation, due to inappropriate immune responses …

Virus-derived sequences and transposable elements constitute a substantial portion of
many cellular genomes. Recent insights reveal the intimate evolutionary relationship …

Organ transplantation has progressed with the comprehension of the major
histocompatibility complex (MHC). It is true that the outcome of organ transplantation largely …

The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing
selection, and variation at these loci is associated with many disease phenotypes. Variation …