Interferon signaling in cancer. Non-canonical pathways and control of intracellular immune checkpoints

D Saleiro, LC Platanias - Seminars in immunology, 2019 - Elsevier
The interferons (IFNs) are cytokines with important antineoplastic and immune modulatory
effects. These cytokines have been conserved through evolution as important elements of …

Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-α-induced VCAM-1 expression and monocytic cell adhesion

X Fan, X Chen, Q Feng, K Peng, Q Wu… - American Journal …, 2019 - journals.physiology.org
Increased expression of vascular cell adhesion molecule 1 (VCAM-1) on the aortic
endothelium is an early marker of atherogenesis, promoted in part by elevated levels of …

[HTML][HTML] Regulation of protein kinase Cδ nuclear import and apoptosis by mechanistic target of rapamycin complex-1

A Layoun, AA Goldberg, A Baig, M Eng, O Attias… - Scientific reports, 2019 - nature.com
Inactivation of the protein complex 'mechanistic target of rapamycin complex 1'(mTORC1)
can increase the nuclear content of transcriptional regulators of metabolism and apoptosis …

Computational analysis of cis-regulatory mechanisms underlying cellular response to drug perturbations

CR Hanson - 2019 - ideals.illinois.edu
In this thesis, I, alongside my varied and talented collaborators, aim to integrate two
seemingly disparate subfields of biology: pharmacogenomics and regulatory genomics. The …

[HTML][HTML] Vascular Biology and Microcirculation: Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-α-induced VCAM-1 …

X Fan, X Chen, Q Feng, K Peng, Q Wu… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Increased expression of vascular cell adhesion molecule 1 (VCAM-1) on the aortic
endothelium is an early marker of atherogenesis, promoted in part by elevated levels of …