Studying fungal pathogens of humans and fungal infections: Fungal diversity and diversity of approaches

G Janbon, J Quintin, F Lanternier, C d'Enfert - Microbes and Infection, 2019 - Elsevier
Abstract Seminal work by Louis Pasteur revealed the contribution of fungi–yeasts and
microsporidia to agroindustry and disease in animals, respectively. More than 150 years …

Life Cycle of Cryptococcus neoformans

Y Zhao, J Lin, Y Fan, X Lin - Annual review of microbiology, 2019 - annualreviews.org
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

Z Chang, RB Billmyre, SC Lee, J Heitman - PLoS Genetics, 2019 - journals.plos.org
Mucormycosis—an emergent, deadly fungal infection—is difficult to treat, in part because the
causative species demonstrate broad clinical antifungal resistance. However, the …

The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi

S Sun, MA Coelho, M David-Palma… - Annual review of …, 2019 - annualreviews.org
Cryptococcus species utilize a variety of sexual reproduction mechanisms, which generate
genetic diversity, purge deleterious mutations, and contribute to their ability to occupy myriad …

Chromatin-mediated regulation of genome plasticity in human fungal pathogens

A Buscaino - Genes, 2019 - mdpi.com
Human fungal pathogens, such as Candida albicans, Aspergillus fumigatus and
Cryptococcus neoformans, are a public health problem, causing millions of infections and …

A non-dicer RNase III and four other novel factors required for RNAi-mediated transposon suppression in the human pathogenic yeast Cryptococcus neoformans

JE Burke, AD Longhurst, P Natarajan… - G3: Genes …, 2019 - academic.oup.com
The human pathogenic yeast Cryptococcus neoformans silences transposable elements
using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA …

RNA interference core components identified and characterised in Verticillium nonalfalfae, a vascular wilt pathogenic plant fungi of hops

T Jeseničnik, N Štajner, S Radišek, J Jakše - Scientific reports, 2019 - nature.com
The conserved RNA interference mechanism (RNAi) in the fungal kingdom has become a
focus of intense scientific investigation. The three catalytic core components, Dicer-like …

Phenotypic instability in fungi

P Silar - Advances in Applied Microbiology, 2019 - Elsevier
Fungi are prone to phenotypic instability, that is, the vegetative phase of these organisms, be
they yeasts or molds, undergoes frequent switching between two or more behaviors, often …

格特隐球菌基因组学研究进展

贾鑫淼, 肖盟, 孙天舒, 徐英春 - 协和医学杂志, 2019 - xhyxzz.pumch.cn
格特隐球菌属于新生隐球菌复合体, 既往被认为是新生隐球菌复合体的变种,
但最终被确立为独立的物种. 与新生隐球菌不同, 格特隐球菌多感染免疫力正常人群 …

Mating-type specific divergent RPL22 paralogs are essential, differentially regulated, and control aspects of sexual reproduction in Cryptococcus neoformans

G Ianiri, YF Fang, TA Dahlmann, G Janbon, U Kück… - bioRxiv, 2019 - biorxiv.org
The MAT locus of Cryptococcus neoformans has a bipolar organization characterized by an
unusually large structure, spanning over 100 kb. MAT genes have been characterized by …