To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system
A Hage, R Rajsbaum - Journal of General Virology, 2019 - microbiologyresearch.org
The innate immune system responds rapidly to protect against viral infections, but an
overactive response can cause harmful damage. To avoid this, the response is tightly …
overactive response can cause harmful damage. To avoid this, the response is tightly …
E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity
Y Zheng, C Gao - Cellular immunology, 2019 - Elsevier
During viral infection, the innate immune system represents the first defense line of the
human body. The pathogen associated molecular patterns (PAMPs) from the viruses are …
human body. The pathogen associated molecular patterns (PAMPs) from the viruses are …
Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for …
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein
43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established …
43 (FTLD-TDP) represents the most common pathological subtype of FTLD. We established …
FTRCA1, a species-specific member of finTRIM family, negatively regulates fish IFN response through autophage-lysosomal degradation of TBK1
M Wu, X Zhao, XY Gong, Y Wang, JF Gui… - The Journal of …, 2019 - journals.aai.org
In mammals, tripartite motif (TRIM) proteins have emerged as pivotal players endowed with,
directly, antiviral effects and, indirectly, modulatory capacity of the innate immune response …
directly, antiviral effects and, indirectly, modulatory capacity of the innate immune response …
Porcine RING finger protein 114 inhibits classical swine fever virus replication via K27-linked polyubiquitination of viral NS4B
Y Zhang, H Zhang, GL Zheng, Q Yang, S Yu… - Journal of …, 2019 - Am Soc Microbiol
In the host, many RING domain E3 ligases have been reported to inhibit viral replication
through various mechanisms. In a previous screen, we found that porcine RING finger …
through various mechanisms. In a previous screen, we found that porcine RING finger …
Characterisation and function of TRIM23 in grass carp (Ctenopharyngodon idella)
P Chu, L He, C Yang, Y Li, R Huang, L Liao, Y Li… - Fish & Shellfish …, 2019 - Elsevier
Tripartite motif (TRIM) proteins are key components of the innate immune system,
functioning as antiviral restriction factors or modulating signaling cascades that lead to …
functioning as antiviral restriction factors or modulating signaling cascades that lead to …
[HTML][HTML] Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells
M Maekawa, H Hiyoshi, J Nakayama, K Kido… - Biochemical and …, 2019 - Elsevier
Eukaryotic translation initiation factor 3 subunit D (EIF3D) binds to the 5′-cap of specific
mRNAs, initiating their translation into polypeptides. From a pathological standpoint, EIF3D …
mRNAs, initiating their translation into polypeptides. From a pathological standpoint, EIF3D …
[HTML][HTML] Establishment of SYBR Green I Real-time PCR for Quantitative Detection of TRIM21 Gene
Z Kexue, XU Shujuan, MA Ruixian, G Jinjing… - 热带生物 …, 2019 - rdswxb.hainanu.edu.cn
TRIM21 is closely associated with cancer, tumor, and innate immunity, etc. In order to detect
TRIM21 gene expression quickly, primers were designed and synthesized according to the …
TRIM21 gene expression quickly, primers were designed and synthesized according to the …