Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms
allowing integration of genetic and environmental factors to shape cellular function. While …

Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …

Eating disorders are complex heritable conditions influenced by both genetic and
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …

Alternative splicing (AS) is a widespread process that increases structural transcript variation
and proteome diversity. Aberrant splicing patterns are frequently observed in cancer …

DNA methylation is an important epigenetic mechanism for regulating gene expression.
Aberrant DNA methylation has been observed in various human diseases, including cancer …

Background and objective Ankylosing spondylitis is a chronic inflammatory disease
characterized by inflammation of the sacroiliac joints and the spine that can lead to …

Advances in chromatin state mapping, high-throughput DNA sequencing, and bioinformatics
have revolutionized the study and interpretability of epigenomic variation. The increasing …