The liver is one of the largest organs in the body and is responsible for a diverse repertoire
of metabolic processes. Such processes include the secretion of serum proteins …

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

Recent advancements in the production of hepatocytes from human pluripotent stem cells
(hPSC-Heps) afford tremendous possibilities for treatment of patients with liver disease …

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

The liver plays a pivotal role in whole-body carbohydrate, lipid, and protein metabolism. One
of the key regulators of glucose and lipid metabolism are hepatokines, which are found …

Aim: Primary human hepatocytes (PHHs) undergo dedifferentiation upon the two-
dimensional (2D) culture, which particularly hinders their utility in long-term in vitro studies …

The transcription factor NRF2, governed by its repressor KEAP1, protects cells against
oxidative stress. There is interest in modelling the NRF2 response to improve the prediction …

For fasiglifam (TAK875) and its metabolites the substance‐specific mechanisms of liver
toxicity were studied. Metabolism studies were run to identify a putatively reactive acyl …

Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with
hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate …