Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
The brain NGF metabolic pathway in health and in Alzheimer's pathology
Emerging research has re-emphasized the role of the cortical cholinergic system in the
symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) …
symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) …
Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands
L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …
cause of death worldwide. The number of people suffering from this debilitating disorder is …
Virtual screening, pharmacokinetics, molecular dynamics and binding free energy analysis for small natural molecules against cyclin-dependent kinase 5 for …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and characterized by
brain cell death, memory loss and is the most common form of dementia. Although AD has …
brain cell death, memory loss and is the most common form of dementia. Although AD has …
Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors
Alzheimer's disease is a progressive neurodegenerative disorder causing common health
problem with increasing age. Evidences show that the key symptoms of AD are mainly …
problem with increasing age. Evidences show that the key symptoms of AD are mainly …
Moringa oleifera seed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of …
Methotrexate (MTX) is an effective antineoplastic drug associated with wide organ toxicity.
Accumulating evidence implicates oxidative stress to be a leading underlying mechanism of …
Accumulating evidence implicates oxidative stress to be a leading underlying mechanism of …
Identification of novel small molecules against GSK3β for Alzheimer's disease using chemoinformatics approach
Alzheimer's disease is a rapidly increasing neurodegenerative disease. It is a multifactorial
disease and also a global threat. Several enzymes are implicated in the disease in which …
disease and also a global threat. Several enzymes are implicated in the disease in which …
Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field
Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive
dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in …
dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in …
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands
DA Rodríguez-Soacha, M Scheiner… - European Journal of …, 2019 - Elsevier
In this review, we present the latest advances in the field of multi-target-directed ligand
(MTDL) design for the treatment of various complex pathologies of multifactorial origin. In …
(MTDL) design for the treatment of various complex pathologies of multifactorial origin. In …