Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …

The problem of missing heritability, that is to say the gap between heritability estimates from
genotype data and heritability estimates from twin data, has been a source of debate for …

A central question in human genetics is to find the proportion of variation in a trait that can be
ex-plained by genetic variation. A number of methods have been developed to estimate this …

The contribution of gene-environment (GxE) interactions for many human traits and diseases
is poorly characterised. We propose a Bayesian whole genome regression model, LEMMA …

Linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML)
are a key variance partitioning tool, where effects of multiple sources, such as different …

Despite longstanding interest in gene-by-environment (GxE) interactions, the contribution of
GxE interactions to complex disease in humans remains poorly characterised. Studies of …