The future of genomic studies must be globally representative: perspectives from PAGE
SA Bien, GL Wojcik, CJ Hodonsky… - Annual review of …, 2019 - annualreviews.org
The past decade has seen a technological revolution in human genetics that has
empowered population-level investigations into genetic associations with phenotypes …
empowered population-level investigations into genetic associations with phenotypes …
Runs of homozygosity in sub-Saharan African populations provide insights into complex demographic histories
FC Ceballos, S Hazelhurst, M Ramsay - Human genetics, 2019 - Springer
The study of runs of homozygosity (ROH) can shed light on population demographic history
and cultural practices. We present a fine-scale ROH analysis of 1679 individuals from 28 …
and cultural practices. We present a fine-scale ROH analysis of 1679 individuals from 28 …
Impact of APOL1 Genetic Variants on HIV-1 Infection and Disease Progression
Apolipoprotein L1 (APOL1) has broad innate immune functions and has been shown to
restrict HIV replication in vitro by multiple mechanisms. Coding variants in APOL1 are …
restrict HIV replication in vitro by multiple mechanisms. Coding variants in APOL1 are …
Low prevalence of Apolipoprotein L1 gene variants in black South Africans with hypertension-attributed chronic kidney disease
NU Nqebelele, C Dickens, T Dix-Peek… - Clinical …, 2019 - search.proquest.com
Variants in apolipoprotein L1 (APOL1) gene were shown to be associated with higher rates
of nondiabetic kidney disease in black patients compared with white patients. Frequencies …
of nondiabetic kidney disease in black patients compared with white patients. Frequencies …
Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa
MC Campbell, LT Smith, J Harvey - Genes & Immunity, 2019 - nature.com
Despite its critical role in the defense against microbial infection and tumor development,
little is known about the range of nucleotide and haplotype variation at IFN-γ, or the …
little is known about the range of nucleotide and haplotype variation at IFN-γ, or the …
Innate Antibodies, Murine Models, and Evolution: A Study of Trypanosome Lytic Factor Functions and Their Translational Applications
JP Verdi - 2019 - search.proquest.com
Trypanosome lytic factors (TLFs) are primate-specific antimicrobial protein complexes that
lyse African trypanosome parasites by delivering the channel-forming toxin APOL1 to the …
lyse African trypanosome parasites by delivering the channel-forming toxin APOL1 to the …
Evolutionary Triangulation: Filtering Genetic Associations With Evolutionary Evidence
M Huang - 2019 - search.proquest.com
Agnostic tests of genetic association such as genome wide association studies (GWAS)
have revolutionized how modern human genetic studies are performed. However, despite …
have revolutionized how modern human genetic studies are performed. However, despite …