Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …

Schizophrenia is a heritable complex phenotype associated with a background risk
involving multiple common genetic variants of small effect and a multitude of environmental …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

Objective: Pharmacogenomic studies of antipsychotics have typically examined effects of
individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome …

Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Understanding whether and how the schizophrenia polygenic risk score (SZ PRS) predicts
course of illness could improve diagnosis and prognostication in psychotic disorders. We …

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

Advances in high-throughput genotyping and next-generation sequencing (NGS) coupled
with larger sample sizes brings the realization of precision medicine closer than ever …

Background Callous-unemotional (CU) traits represent the affective features of psychopathy
used to delineate youth at high risk for externalizing pathology. The genetic etiology CU …