A survey on multimodal data-driven smart healthcare systems: approaches and applications
Q Cai, H Wang, Z Li, X Liu - IEEE Access, 2019 - ieeexplore.ieee.org
Multimodal data-driven approach has emerged as an important driving force for smart
healthcare systems with applications ranging from disease analysis to triage, diagnosis and …
healthcare systems with applications ranging from disease analysis to triage, diagnosis and …
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study
Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …
investigated in observational studies; however, the extent of any causal effect remains …
Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study
Background Vitamin D deficiency is highly prevalent across the globe. Existing studies
suggest that a low vitamin D level is associated with more than 130 outcomes. Exploring the …
suggest that a low vitamin D level is associated with more than 130 outcomes. Exploring the …
Methods for the analysis and interpretation for rare variants associated with complex traits
With the advent of Next Generation Sequencing (NGS) technologies, whole genome and
whole exome DNA sequencing has become affordable for routine genetic studies. Coupled …
whole exome DNA sequencing has become affordable for routine genetic studies. Coupled …
Reverse GWAS: Using genetics to identify and model phenotypic subtypes
Recent and classical work has revealed biologically and medically significant subtypes in
complex diseases and traits. However, relevant subtypes are often unknown, unmeasured …
complex diseases and traits. However, relevant subtypes are often unknown, unmeasured …
Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record
Background The growth of DNA biobanks linked to data from electronic health records
(EHRs) has enabled the discovery of numerous associations between genomic variants and …
(EHRs) has enabled the discovery of numerous associations between genomic variants and …
Bayesian meta‐analysis across genome‐wide association studies of diverse phenotypes
Genome‐wide association studies (GWAS) are a powerful tool for understanding the genetic
basis of diseases and traits, but most studies have been conducted in isolation, with a focus …
basis of diseases and traits, but most studies have been conducted in isolation, with a focus …
Extrahepatic autoimmune diseases in patients with autoimmune hepatitis and their relatives: A Danish nationwide cohort study
L Grønbæk, H Vilstrup, L Pedersen… - Liver …, 2019 - Wiley Online Library
Abstract Background & Aims It is widely accepted that patients with autoimmune hepatitis
have an increased prevalence of extrahepatic autoimmune diseases. It is believed that the …
have an increased prevalence of extrahepatic autoimmune diseases. It is believed that the …
The Future of and Beyond GWAS
T Tsunoda - Genome-Wide Association Studies, 2019 - Springer
Although GWAS technologies themselves have become mature, there are still many issues
to be solved. One such issue is the missing heritability problem. It is still unknown whether it …
to be solved. One such issue is the missing heritability problem. It is still unknown whether it …
Efficient estimation and applications of cross-validated genetic predictions
Large-scale cohorts with combined genetic and phenotypic data, coupled with
methodological advances, have produced increasingly accurate genetic predictors of …
methodological advances, have produced increasingly accurate genetic predictors of …