The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

The intestinal microbiota is a dynamic community of bacteria, fungi, and viruses that
mediates mucosal homeostasis and physiology. Imbalances in the microbiome and aberrant …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Abstract Background Checkpoint inhibitors (CIs) are highly effective but can induce severe
immune-related adverse events (irAEs), which cannot be predicted. We investigated …

Background Few studies have examined the association between inflammatory bowel
disease (IBD) and Parkinson's disease (PD). Methods To estimate the incidence and relative …

Background Inflammatory bowel disease (IBD) is a chronic complex disease of the
gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the …

Inflammatory bowel disease (IBD) is a complex disorder associated with a dysregulated
immune response to environmental triggers in the genetically susceptible host. The …

Natural killer (NK) cells can recognize virus-infected and stressed cells using activating and
inhibitory receptors, many of which interact with HLA class I. Although early studies also …

Many immune diseases occur at different rates among people with schizophrenia compared
to the general population. Here, we evaluated whether this phenomenon might be explained …

The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however,
increased and persistent intestinal inflammation, due to inappropriate immune responses …