Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

The Mediterranean basin is especially sensitive to the adverse outcomes of climate change
and especially to variations in rainfall patterns and the incidence of extremely high …

Protein complexes are key macromolecular machines of the cell, but their description
remains incomplete. We and others previously reported an experimental strategy for global …

Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms
through which they contribute to ASD pathophysiology remain elusive. Here we analyzed …

Background Elucidation of regulatory networks, including identification of regulatory
mechanisms specific to a given biological context, is a key aim in systems biology. This has …

Mitochondrial protein (MP) assemblies undergo alterations during neurogenesis, a complex
process vital in brain homeostasis and disease. Yet which MP assemblies remodel during …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Parkinson's disease (PD) is a neurodegenerative disorder involving progressive
deterioration of dopaminergic neurons. Although few genetic markers for familial PD are …

More reliable and cheaper sequencing technologies have revealed the vast mutational
landscapes characteristic of many phenotypes. The analysis of such genetic variants has led …

Motivation Functional enrichment testing methods can reduce data comprising hundreds of
altered biomolecules to smaller sets of altered biological 'concepts' that help generate …