Monocytes and macrophages contribute to pathogenesis of various inflammatory diseases,
including auto-inflammatory diseases, cancer, sepsis, or atherosclerosis. They do so by …

During neural tube closure and spinal cord development, many cells die in both the central
and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived …

Silver nanoparticles (AgNP) are widely used in a variety of consumable products as
antibacterial to prevent or treat infection. Unfortunately, evidence exits that AgNP induces …

Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene
expression and pathways. Although some adjuvants have been approved for commercial …

The expression and activity of main inflammasome components in monocytes from
successfully treated human immunodeficiency virus (HIV)–positive patients are poorly …

Dendritic cells (DCs) regulate immunity and inflammation and respond to various stimuli,
including cytokines. IL-1β is a key cytokine in the course of both acute and chronic …

Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for
microglia depletion, with the assumption that it does not affect peripheral immune cells …

Abstract Interleukin-1β (IL-1β) is a proinflammatory cytokine and an important component of
innate immunity. However, overproduction of IL-1β is implicated in a number of …

Previous studies have suggested that microglia depletion using small molecule
colonystimulating factor 1 receptor (CSF1R) inhibitor, does not affect peripheral immune …

Immune checkpoint inhibition represents a promising approach for multiple malignancies.
Why successful T cell responses are achieved in only some patients is not well understood …