[HTML][HTML] Molecular mechanisms of zinc as a pro-antioxidant mediator: clinical therapeutic implications

AS Prasad, B Bao - Antioxidants, 2019 - mdpi.com
The essentiality of zinc as a trace mineral in human health has been recognized for over five
decades. Zinc deficiency, caused by diet, genetic defects, or diseases, can cause growth …

[HTML][HTML] Impact of ROS generated by chemical, physical, and plasma techniques on cancer attenuation

S Mitra, LN Nguyen, M Akter, G Park, EH Choi… - Cancers, 2019 - mdpi.com
For the last few decades, while significant improvements have been achieved in cancer
therapy, this family of diseases is still considered one of the deadliest threats to human …

Artificially reprogrammed macrophages as tumor‐tropic immunosuppression‐resistant biologics to realize therapeutics production and immune activation

CX Li, Y Zhang, X Dong, L Zhang, MD Liu… - Advanced …, 2019 - Wiley Online Library
To engineer patient‐derived cells into therapy‐purposed biologics is a promising solution to
realize personalized treatments. Without using gene‐editing technology, a live cell‐typed …

[HTML][HTML] Quantification of hydrogen peroxide by electrochemical methods and electron spin resonance spectroscopy

R Gulaboski, V Mirčeski, R Kappl… - Journal of The …, 2019 - iopscience.iop.org
Reactive oxygen species (ROS) exhibit different spatial and temporal distributions as well as
concentrations in-and outside the cell, thereby functioning as signaling or pathogen …

[HTML][HTML] Glutathione induced immune-stimulatory activity by promoting M1-like macrophages polarization via potential ROS scavenging capacity

DH Kwon, H Lee, C Park, SH Hong, SH Hong, GY Kim… - Antioxidants, 2019 - mdpi.com
The present study investigated the immunomodulatory activity of reduced glutathione (GSH)
by assessment of the macrophage polarization (MP)-mediated immune response in RAW …

Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?

LES de Groot, TA Van Der Veen… - … of physiology-lung …, 2019 - journals.physiology.org
Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic
obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells …

[HTML][HTML] Metabolic reprogramming in mitochondria of myeloid cells

H Zuo, Y Wan - Cells, 2019 - mdpi.com
The myeloid lineage consists of multiple immune cell types, such as macrophages,
monocytes, and dendritic cells. It actively participates in both innate and adaptive immunity …

Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA

K Tomita, Y Takashi, Y Ouchi, Y Kuwahara… - Cancer …, 2019 - Wiley Online Library
Hydroxynonenal (HNE) is an important product of plasma membrane lipid peroxidation,
which is a cause of cell and tissue injury. Mitochondrial DNA (mtDNA)‐depleted ρ0 cells …

Inflammation and (secondary) genotoxicity of Ni and NiO nanoparticles

E Åkerlund, MS Islam, S McCarrick… - …, 2019 - Taylor & Francis
Nanoparticle-induced genotoxicity can arise through different mechanisms, and generally,
primary and secondary genotoxicity can be distinguished where the secondary is driven by …

Preservation of post-infarction cardiac structure and function via long-term oral formyl peptide receptor agonist treatment

RA García, BR Ito, JA Lupisella, NA Carson… - JACC: Basic to …, 2019 - jacc.org
Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV)
remodeling and loss of function. Targeting inflammation resolution by activating formyl …