Innate immunity provides the initial defence against infection and it is now clear that long
non-coding RNAs (lncRNAs) are important regulators of this response. Following activation …

Induction of interferons during viral infection is mediated by cellular proteins that recognise
viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA …

RNA-binding proteins (RBPs) play essential roles in biology and are frequently associated
with human disease. Although recent studies have systematically identified individual RNA …

Abstract Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate
immune response to viral infection. How this response can be enhanced, however, remains …

Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that
regulate gene expression at the transcriptional and post-transcriptional levels. Emerging …

Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the
modulation and control of multiple biological processes. Distinct classes of lncRNAs are now …

Type I and type III interferons are important anti-viral cytokines that are massively induced
during viral infection. This dynamic process is regulated by many executors and regulators …

In conjunction with the development of genome-wide technology, numerous studies have
revealed the importance of regulatory mechanisms to avoid the onset of autoimmunity. In …

Immune responses are both pathogen and cell type-specific. The innate arm of immunity is
characterized by rapid intracellular signaling cascades resulting in the production of …

Multiple host factors are known to play important roles in hepatitis C virus (HCV) replication,
in immune responses induced by HCV infection, or in processes that facilitate virus escape …