[HTML][HTML] Developmental trajectories of early life stress and trauma: a narrative review on neurobiological aspects beyond stress system dysregulation

A Agorastos, P Pervanidou, GP Chrousos… - Frontiers in …, 2019 - frontiersin.org
Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

GF Mattina, RJ Van Lieshout… - Therapeutic advances in …, 2019 - journals.sagepub.com
Women are at increased risk for developing depression and cardiovascular disease (CVD)
across the lifespan and their comorbidity is associated with adverse outcomes that …

Lonely young adults in modern Britain: findings from an epidemiological cohort study

T Matthews, A Danese, A Caspi, HL Fisher… - Psychological …, 2019 - cambridge.org
BackgroundThe aim of this study was to build a detailed, integrative profile of the correlates
of young adults' feelings of loneliness, in terms of their current health and functioning and …

Intergenerational transmission of depression: clinical observations and molecular mechanisms

KM Sawyer, PA Zunszain, P Dazzan… - Molecular psychiatry, 2019 - nature.com
Maternal mental illness can have a devastating effect during the perinatal period, and has a
profound impact on the care that the baby receives and on the relationships that the baby …

Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study

H Song, K Fall, F Fang, H Erlendsdóttir, D Lu… - bmj, 2019 - bmj.com
Objective To assess whether severe psychiatric reactions to trauma and other adversities
are associated with subsequent risk of life threatening infections. Design Population and …

Old Friends, immunoregulation, and stress resilience

D Langgartner, CA Lowry, SO Reber - Pflügers Archiv-European Journal …, 2019 - Springer
There is a considerable body of evidence indicating that chronic adverse experience,
especially chronic psychosocial stress/trauma, represents a major risk factor for the …

Role of inflammation in depression and treatment implications

JC Felger - Antidepressants: From Biogenic Amines to New …, 2019 - Springer
Approximately one third of depressed patients fail to respond to currently available
antidepressant therapies. Therefore, new conceptual frameworks are needed to identify …

Retrospectively reported childhood physical abuse, systemic inflammation, and resting corticolimbic connectivity in midlife adults

TE Kraynak, AL Marsland, JL Hanson… - Brain, Behavior, and …, 2019 - Elsevier
Childhood abuse confers risk for psychopathology and pathophysiology in midlife through
intermediate pathways that remain unclear. Systemic inflammation was tested in the present …

Pathways between early‐life adversity and adolescent self‐harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children

AE Russell, J Heron, D Gunnell, T Ford… - Journal of child …, 2019 - Wiley Online Library
Background Adverse childhood experiences (ACEs) such as physical and emotional abuse
are strongly associated with self‐harm, but mechanisms underlying this relationship are …

Neuroimmune impacts of early-life stress on development and psychopathology

HC Brenhouse, A Danese, R Grassi-Oliveira - … regulation of behavior, 2019 - Springer
Maltreatment and trauma in childhood, termed early-life stress (ELS), has long-term effects
on the immune system. ELS impacts immune signaling at the time of exposure but also …