DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Polycystic ovary syndrome and mitochondrial dysfunction
J Zhang, Y Bao, X Zhou, L Zheng - Reproductive Biology and …, 2019 - Springer
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal
women worldwide and is characterized by reproductive, endocrine, and metabolic …
women worldwide and is characterized by reproductive, endocrine, and metabolic …
[HTML][HTML] Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease
T Candler, P Kühnen, AM Prentice, M Silver - Frontiers in …, 2019 - Elsevier
Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …
methylation may modulate POMC expression and provide a biological link between early life …
Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study
DNA methylation acts at the interface of genetic and environmental factors relevant for
autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich …
autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich …
DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
NY Souren, LA Gerdes, P Lutsik, G Gasparoni… - Nature …, 2019 - nature.com
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins, which strongly argues for …
system with a modest concordance rate in monozygotic twins, which strongly argues for …
Establishing a generalized polyepigenetic biomarker for tobacco smoking
Large-scale epigenome-wide association meta-analyses have identified multiple
'signatures''of smoking. Drawing on these findings, we describe the construction of a …
'signatures''of smoking. Drawing on these findings, we describe the construction of a …
Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression
Abstract Background Multiple Sclerosis (MS) is a chronic inflammatory disease and a
leading cause of progressive neurological disability among young adults. DNA methylation …
leading cause of progressive neurological disability among young adults. DNA methylation …
[HTML][HTML] Fecal microbiota transplantation: great potential with many challenges
R Kellermayer - Translational gastroenterology and hepatology, 2019 - ncbi.nlm.nih.gov
Abstract In January of 2019, Samuel P. Costello and colleagues published a wonderfully
executed, double blind placebo-controlled trial on fecal microbiota transplantation (FMT) …
executed, double blind placebo-controlled trial on fecal microbiota transplantation (FMT) …
Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle
Background DNA methylation has been shown to be involved in many biological processes,
including X chromosome inactivation in females, paternal genomic imprinting, and others …
including X chromosome inactivation in females, paternal genomic imprinting, and others …
RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation
Background A gap exists in our mechanistic understanding of how genetic and
environmental risk factors converge at the molecular level to result in the emergence of …
environmental risk factors converge at the molecular level to result in the emergence of …