The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

Dipeptidyl peptidase-4 (DPP-4), also known as the T-cell antigen CD26, is a multi-functional
protein which, besides its catalytic activity, also functions as a binding protein and a ligand …

GLP-1, a peptide hormone secreted from the gut, stimulating insulin and suppressing
glucagon secretion was identified as a parent compound for novel treatments of diabetes …

Researchers have been looking for insulin-stimulating factors for more than 100 years, and
in the 1960ties it was definitively proven that the gastrointestinal tract releases important …

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate
energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 …

Type 2 diabetes mellitus (T2DM) is increasing in global prevalence and is associated with
serious health problems (eg, cardiovascular disease). Various treatment options are …

Abstract BACKGROUND Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs)
have become firmly established in the treatment of type 2 diabetes and obesity, disorders …

The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's
disease (PD) reflects an incomplete knowledge of the underlying disease processes …