Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities
The TCF4 gene is the subject of numerous and varied investigations of it's role in the
genesis of neuropsychiatric disease. The gene has been identified as the cause of Pitt …
genesis of neuropsychiatric disease. The gene has been identified as the cause of Pitt …
Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia
A Doostparast Torshizi, C Armoskus, H Zhang… - Science …, 2019 - science.org
Applying tissue-specific deconvolution of transcriptional networks to identify their master
regulators (MRs) in neuropsychiatric disorders has been largely unexplored. Here, using …
regulators (MRs) in neuropsychiatric disorders has been largely unexplored. Here, using …
Vaccinia‐related kinase 2 plays a critical role in microglia‐mediated synapse elimination during neurodevelopment
J Lee, S Lee, YJ Ryu, D Lee, S Kim, JY Seo, E Oh… - Glia, 2019 - Wiley Online Library
During postnatal neurodevelopment, excessive synapses must be eliminated by microglia to
complete the establishment of neural circuits in the brain. The lack of synaptic regulation by …
complete the establishment of neural circuits in the brain. The lack of synaptic regulation by …
Functional characterization of two variants in the 3'-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from …
Abstract Transcription factor 4 (TCF4) gene plays an important role in nervous system
development and it always associated with the risk of schizophrenia. Since miRNAs regulate …
development and it always associated with the risk of schizophrenia. Since miRNAs regulate …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
23 and Me Research Team - Nature …, 2019 - research-information.bris.ac.uk
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
HNRNP Q suppresses polyglutamine huntingtin aggregation by post‐transcriptional regulation of vaccinia‐related kinase 2
Misfolded proteins with abnormal polyglutamine (polyQ) expansion cause
neurodegenerative disorders, including Huntington's disease. Recently, it was found that …
neurodegenerative disorders, including Huntington's disease. Recently, it was found that …
[HTML][HTML] Genetic variability of TCF4 in schizophrenia of Southern Chinese Han population: a case-control study
J Yin, D Zhu, Y Li, D Lv, H Yu, C Liang, X Luo… - Frontiers in …, 2019 - frontiersin.org
Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a key regulator
in the development of the central nervous system, transcription factor 4 (TCF4) has been …
in the development of the central nervous system, transcription factor 4 (TCF4) has been …