Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

The FANTOM web resource (http://fantom. gsc. riken. jp/) was developed to provide easy
access to the data produced by the FANTOM project. It contains the most complete and …

Owing to safety concerns or insufficient efficacy, few drug candidates are approved for
marketing. Drugs already on the market may be withdrawn due to adverse effects (AEs) …

Abstract mRNA processing events introduce an intricate layer of complexity into gene
expression processes, supporting a tremendous level of diversification of the genome's …

CD4 T cells are major immune cell types that mediate effector responses appropriate for
diverse incoming threats. These cells have been categorized into different subsets based on …

Natural antisense transcripts are common features of mammalian genes providing
additional regulatory layers of gene expression. A comprehensive description of antisense …

Subtype-specific leukemia oncogenes drive aberrant gene expression profiles that converge
on common essential mediators to ensure leukemia self-renewal and inhibition of …

The process of direct cell reprogramming, also named transdifferentiation, permits for the
conversion of one mature cell type directly into another, without returning to a …

The interactions between proteins and DNA play critical roles in numerous essential cellular
activities. Therefore, sensitive investigation of these interactions is crucial for the study of …

Although it is well appreciated that gene expression is inherently noisy and that
transcriptional noise is encoded in a promoter's sequence, little is known about the variation …