Global HIV neurology: a comprehensive review

KT Thakur, A Boubour, D Saylor, M Das, DR Bearden… - Aids, 2019 - journals.lww.com
Neurological conditions associated with HIV remain major contributors to morbidity and
mortality and are increasingly recognized in the aging population on long-standing …

[PDF][PDF] The impact of HIV-1 drug escape on the global treatment landscape

DA Collier, C Monit, RK Gupta - Cell host & microbe, 2019 - cell.com
The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in
combating the HIV epidemic and compromise the 90-90-90 target proposed by United …

Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance

S Spudich, KR Robertson, RJ Bosch… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND Persistence of HIV in sanctuary sites despite antiretroviral therapy (ART)
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …

Human immunodeficiency virus type 1 RNA detected in the central nervous system (CNS) after years of suppressive antiretroviral therapy can originate from a …

SB Joseph, LP Kincer, NM Bowman… - Clinical Infectious …, 2019 - academic.oup.com
Background Human immunodeficiency virus type 1 (HIV-1) populations are detected in
cerebrospinal fluid (CSF) of some people on suppressive antiretroviral therapy (ART) …

Cerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy: prevalence, risk factors and neurocognitive effects

I Pérez-Valero, R Ellis, R Heaton, R Deutsch… - Aids, 2019 - journals.lww.com
Background: During antiretroviral therapy, HIV RNA can be detected in cerebrospinal fluid
(CSF) when it is undetectable in plasma, a condition termed 'CSF viral escape'. The aim of …

Extracellular vesicles: a possible link between HIV and Alzheimer's disease-like pathology in HIV subjects?

S Kodidela, K Gerth, S Haque, Y Gong, S Ismael… - Cells, 2019 - mdpi.com
The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral
therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV …

Defining cerebrospinal fluid HIV RNA escape: editorial review AIDS

A Winston, A Antinori, P Cinque, HS Fox, M Gisslen… - Aids, 2019 - journals.lww.com
Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy.
Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal …

Cross-sectional and cumulative longitudinal central nervous system penetration effectiveness scores are not associated with neurocognitive impairment in a well …

GMA Santos, I Locatelli, M Métral… - Open forum …, 2019 - academic.oup.com
Background Neurocognitive impairment (NCI) in people with human immunodeficiency virus
(PWH) remains a concern despite potent antiretroviral therapy (ART). Higher central nervous …

Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence

S Spudich, J Peterson, D Fuchs, RW Price, M Gisslen - Aids, 2019 - journals.lww.com
Although treatment with antiretroviral therapy (ART) improves central nervous inflammation,
limits viral replication detected in the cerebrospinal fluid, and prevents severe clinical …

What can characterization of cerebrospinal fluid escape populations teach us about viral reservoirs in the central nervous system?

SB Joseph, M Trunfio, LP Kincer, A Calcagno… - Aids, 2019 - journals.lww.com
Objective: To review the evidence that CSF (cerebrospinal fluid) escape populations are
produced by viral reservoirs in the central nervous system (CNS). Design: CSF escape is a …