Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

The proper function of the organs that make up the urinary tract (kidneys, ureters, bladder,
and urethra) depends on their ability to sense and respond to mechanical forces, including …

With better serum UMOD detection assays the extent of different functions for UMOD is still
expanding. Urinary UMOD regulates different tubular ion channels and cotransporters …

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick
ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the …

Recent human genetic studies have suggested an intriguing link between ciliary signaling
defects and altered DNA damage responses in nephronophthisis (NPH) and related …

Uromodulin, the most abundant protein in urine, is synthesized in the thick ascending loop of
Henle and distal convoluted tubules. Patients with chronic kidney disease (CKD) have …

Protein misfolding may be the result of a variety of different processes that disrupt the ability
of a protein to form a thermodynamically stable tertiary structure that allows it to perform its …

We investigated type 2 diabetes (T2D) genetic susceptibility in a multi-ethnic meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP) and other …

Acute kidney injury (AKI) is a rapid decline of renal function, with an incidence of up to 67%
of intensive care unit patients. Current treatments are merely supportive, emphasizing the …

Résumé L'hypertension artérielle affecte 40% des Canadiens et Canadiennes âgés de 56 à
65 ans et correspond à un facteur de risque important pour le développement de maladies …