The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Ovarian cancer is the deadliest gynecologic malignancy, with a 5-year survival rate of
approximately 47%, a number that has remained constant over the past two decades. Early …

Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​—The Wall Street Journal A
paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of …

Accumulating evidence has indicated that sirtuins are key components of diverse
physiological processes, including metabolism and aging. Sirtuins confer protection from a …

Ribosomopathies are a diverse subset of diseases caused by reduced expression of, or
mutations in, factors necessary for making ribosomes, the protein translation machinery in …

Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid
and extensive gene copy number variation and is implicated in the pathology of cancer and …

rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive
in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for …

Longevity reflects the ability to maintain homeostatic conditions necessary for life as an
organism ages. A long-lived organism must contend not only with environmental hazards …