Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

This review discusses the interplay between multimorbidity (ie co‐occurrence of more than
one chronic health condition in an individual) and functional impairment (ie limitations in …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …

Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …