New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Development and arealization of the cerebral cortex

CR Cadwell, A Bhaduri, MA Mostajo-Radji, MG Keefe… - Neuron, 2019 - cell.com
Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

High-definition spatial transcriptomics for in situ tissue profiling

S Vickovic, G Eraslan, F Salmén, J Klughammer… - Nature …, 2019 - nature.com
Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

M Uhlen, MJ Karlsson, W Zhong, A Tebani, C Pou… - Science, 2019 - science.org
INTRODUCTION Blood is the predominant source for molecular analyses in humans, both in
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

A practical guide to linking brain-wide gene expression and neuroimaging data

A Arnatkevic̆iūtė, BD Fulcher, A Fornito - Neuroimage, 2019 - Elsevier
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

Bridging the gap between connectome and transcriptome

A Fornito, A Arnatkevičiūtė, BD Fulcher - Trends in cognitive sciences, 2019 - cell.com
The recent construction of brain-wide gene expression atlases, which measure the
transcriptional activity of thousands of genes in multiple anatomical locations, has made it …

Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes

SE Morgan, J Seidlitz, KJ Whitaker… - Proceedings of the …, 2019 - National Acad Sciences
Schizophrenia has been conceived as a disorder of brain connectivity, but it is unclear how
this network phenotype is related to the underlying genetics. We used morphometric …

Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury

S Pöyhönen, S Er, A Domanskyi… - Frontiers in physiology, 2019 - frontiersin.org
Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Decoupling of brain function from structure reveals regional behavioral specialization in humans

MG Preti, D Van De Ville - Nature communications, 2019 - nature.com
The brain is an assembly of neuronal populations interconnected by structural pathways.
Brain activity is expressed on and constrained by this substrate. Therefore, statistical …