The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

At early stages of the exponential growth phase in HEK293 cell cultures, the tricarboxylic
acid cycle is unable to process all the amount of NADH generated in the glycolysis pathway …

Metabolic flux analysis based on 13 C-derived constraints has proved to be a powerful
method for quantitative physiological characterisation of one of the most extensively used …

Introduction The switch from quiescence (G0) into G1 and cell cycle progression critically
depends on specific nutrients and metabolic capabilities. Conversely, metabolic networks …

The rapid consumption of large quantities of glucose in conventional CHO batch processes
yields large quantities of lactate, leading to the inhibition of cell growth. We have observed …

A biorefinery comprises a variety of process steps to synthesize products from sustainable
natural resources. Dynamic plant‐wide simulation enhances the process understanding …

Akin to electronic systems that can tune to and process signals of select frequencies,
systems/networks of chemical reactions also “propagate” time‐varying concentration inputs …

Abstract 13C metabolic flux analysis (13C-MFA) has achieved increasing significance in
quantitative metabolic system analysis in recent years. In 13C metabolic flux analysis, 13C …

There is increasing evidence of extensive metabolic changes over the division cycle of
eukaryotic cells. However, quantitative information about how flux redistributes in distinct …

Technological advances in next-generation sequencing and biomedical imaging have led to
a rapid increase in biomedical data dimension and acquisition rate, which is challenging the …