Distinct genome replication and transcription strategies within the growing filovirus family

AJ Hume, E Mühlberger - Journal of molecular biology, 2019 - Elsevier
Research on filoviruses has historically focused on the highly pathogenic ebola-and
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …

[HTML][HTML] Extracellular vesicles and Ebola virus: a new mechanism of immune evasion

ML Pleet, C DeMarino, SW Stonier, JM Dye… - Viruses, 2019 - mdpi.com
Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually
asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of …

Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics

Z Wang, H Liang, H Cao, B Zhang, J Li, W Wang, S Qin… - Analyst, 2019 - pubs.rsc.org
Although natural herbs have been a rich source of compounds for drug discovery,
identification of bioactive components from natural herbs suffers from low efficiency and …

Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex

RN Kirchdoerfer, EO Saphire, AB Ward - … Crystallographica Section F …, 2019 - scripts.iucr.org
Ebola virus is an emerging virus that is capable of causing a deadly disease in humans.
Replication, transcription and packaging of the viral genome are carried out by the viral …

[HTML][HTML] Biomechanical characterization of TIM protein–mediated Ebola virus–host cell adhesion

MA Dragovich, N Fortoul, A Jagota, W Zhang… - Scientific reports, 2019 - nature.com
Since the most recent outbreak, the Ebola virus (EBOV) epidemic remains one of the world's
public health and safety concerns. EBOV is a negative-sense RNA virus that can infect …

[HTML][HTML] Conserved peptide vaccine candidates containing multiple Ebola nucleoprotein epitopes display interactions with diverse HLA molecules

S Jain, M Baranwal - Medical Microbiology and Immunology, 2019 - Springer
Immunoinformatics has come by leaps and bounds to finding potent vaccine candidates
against various pathogens. In the current study, a combination of different T (CD4+ and …

A conformational switch balances viral RNA accessibility and protection in a nucleocapsid ring model

DA Paggi, SA Esperante, M Salgueiro… - Archives of biochemistry …, 2019 - Elsevier
Virus from the Mononegavirales order share common features ranging from virion structure
arrangement to mechanisms of replication and transcription. One of them is the way the …

Structure of the Ebola virus nucleoprotein–RNA complex

RN Kirchdoerfer, EO Saphire, AB Ward - bioRxiv, 2019 - biorxiv.org
Ebola virus is an emerging virus capable of causing a deadly disease in humans.
Replication, transcription and packaging of the viral genome is carried out by the viral …

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W Li - JMIR, 2019 - core.ac.uk
Viral proteases have been shown to be effective targets of anti-viral therapies for human
immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of …