The genomics of schizophrenia: shortcomings and solutions

C Zhuo, W Hou, G Li, F Mao, S Li, X Lin, D Jiang… - Progress in Neuro …, 2019 - Elsevier
Due to recent advances in human genomic technologies, there have been explosive
interests and extensive research on the genomics of schizophrenia, a severe psychiatric …

Stem cell models of schizophrenia, what have we learned and what is the potential?

M Moslem, J Olive, A Falk - Schizophrenia research, 2019 - Elsevier
Schizophrenia is a complex disorder with clinical manifestations in early adulthood.
However, it may start with disruption of brain development caused by genetic or …

Clustering of co‐occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data

T Vargason, RE Frye, DL McGuinness… - Autism …, 2019 - Wiley Online Library
Individuals with autism spectrum disorder (ASD) are frequently affected by co‐occurring
medical conditions (COCs), which vary in severity, age of onset, and pathophysiological …

Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders

L D'Abate, S Walker, RKC Yuen, K Tammimies… - Nature …, 2019 - nature.com
Identification of genetic biomarkers associated with autism spectrum disorders (ASDs) could
improve recurrence prediction for families with a child with ASD. Here, we describe clinical …

Reversal of proliferation deficits caused by chromosome 16p13. 11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal …

M Johnstone, NA Vasistha, MC Barbu, O Dando… - Molecular …, 2019 - nature.com
The molecular basis of how chromosome 16p13. 11 microduplication leads to major
psychiatric disorders is unknown. Here we have undertaken brain imaging of patients …

Copy number variant syndromes are frequent in schizophrenia: progressing towards a CNV-schizophrenia model

V Sriretnakumar, CC Zai, S Wasim… - Schizophrenia …, 2019 - Elsevier
The genetic underpinnings of schizophrenia (SCZ) remain unclear. SCZ genetic studies thus
far have only identified numerous single nucleotide polymorphisms with small effect sizes …

Predicting treatment response using pharmacy register in migraine

TF Hansen, MA Chalmer, TM Haspang… - The Journal of …, 2019 - Springer
Background Precision medicine may offer new strategies to treat migraine, and access to
existing large cohorts may be a key resource to increase statistical power. Treatment …

The psychosis risk timeline: can we improve our preventive strategies? Part 1: early life

K Romain, A Eriksson, R Onyon, M Kumar - BJPsych Advances, 2019 - cambridge.org
Psychosis is a complex presentation with a wide range of factors contributing to its
development, biological and environmental. Psychosis is a feature present in a variety of …

Submicroscopic aberrations of chromosome 16 in prenatal diagnosis

X Wu, L Xu, Y Li, N Lin, L Su, M Cai, X Xie… - Molecular …, 2019 - Springer
Abstract Background Nearly 9.89% of chromosome 16 consists of segmental duplications,
which makes it prone to non-homologous recombination. The present study aimed to …

Genome-wide copy number variation-, validation-and screening study implicates a novel copy number polymorphism associated with suicide attempts in major …

S Rao, M Shi, X Han, MHB Lam, G Liu, YK Wing… - bioRxiv, 2019 - biorxiv.org
Background The genetic basis of suicide attempts (SA) remained unclear, especially for the
copy number variations (CNVs) involved. The present study aimed to identify the …