Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

LF de Sousa Moraes, X Sun… - Critical reviews in food …, 2019 - Taylor & Francis
Colorectal cancer (CRC) is one of the most common cause of cancer death. Phytochemicals,
especially anthocyanins/anthocyanidins (A/A), have gathered attention of the scientific …

Protective effect of kaempferol on LPS-induced inflammation and barrier dysfunction in a coculture model of intestinal epithelial cells and intestinal microvascular …

Y Bian, Y Dong, J Sun, M Sun, Q Hou… - Journal of agricultural …, 2019 - ACS Publications
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of intestinal mucosa
and submucosa, characterized by the disruption of the intestinal epithelial barrier, increased …

QingBai decoction regulates intestinal permeability of dextran sulphate sodium‐induced colitis through the modulation of notch and NF‐κB signalling

JC Lin, JQ Wu, F Wang, FY Tang, J Sun, B Xu… - Cell …, 2019 - Wiley Online Library
Abstract Objective Chinese Herb QingBai decoction (QBD) has been approved affective in
the treatment of IBD patients in clinic. However, the underlying mechanism remains …

[HTML][HTML] Grape peel powder promotes intestinal barrier homeostasis in acute TNBS-colitis: A major role for dietary fiber and fiber-bound polyphenols

LH Maurer, CBB Cazarin, A Quatrin, NM Minuzzi… - Food Research …, 2019 - Elsevier
Inflammatory bowel diseases are characterized by impaired intestinal barrier function. This
study aimed to evaluate the effects of grape peel powder (GPP) and its bioactive rich …

The loss of tolerance to CHI3L1–a putative role in inflammatory bowel disease?

C Deutschmann, D Roggenbuck, P Schierack - Clinical Immunology, 2019 - Elsevier
The incidence of inflammatory bowel disease (IBD) is steadily increasing. IBD is
characterized by chronic inflammation of the gastrointestinal tract and is divided into the two …

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

M Wong, AS Ganapathy, E Suchanec… - … of Physiology-Cell …, 2019 - journals.physiology.org
A defective tight junction (TJ) barrier is a key pathogenic factor for inflammatory bowel
disease. Previously, we have shown that autophagy, a cell survival mechanism, enhances …

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

R Al-Sadi, M Youssef, M Rawat… - American Journal …, 2019 - journals.physiology.org
Matrix metalloproteinase-9 (MMP-9) has been implicated as being an important pathogenic
factor in inflammatory bowel disease (IBD). MMP-9 is markedly elevated in intestinal tissue …

[HTML][HTML] Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

M Bardenbacher, B Ruder, N Britzen-Laurent… - Stem cell …, 2019 - Elsevier
The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the
digestive tract, including inflammatory bowel diseases and colorectal cancer. Intestinal …

[HTML][HTML] Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice

P Giménez-Gómez, M Pérez-Hernández… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Inflammatory processes have been shown to modify tryptophan (Trp) metabolism. Gut
microbiota appears to play a significant role in the induction of peripheral and central …

Anti‐inflammatory effects of Vicenin‐2 on dextran sulfate sodium‐induced colitis in mice

Y Yin, L Ye, Z Niu, W Fang - Drug Development Research, 2019 - Wiley Online Library
The objective of the present work was to evaluate the anti‐inflammatory effects of Vicenin‐2
on dextran sulfate sodium (DSS)‐induced colitis model. Colitis was induced in C57BL/6J …