Dealing with uncertainty is one of practical issues in design and operation of heat exchanger
networks (HENs), arising the problem of flexible HEN synthesis. This paper addresses the …

As a founder of the Process Systems Engineering (PSE) discipline, Professor Roger WH
Sargent had set ambitious goals for a systematic new generation of a process design …

To increase manufacturing flexibility and system understanding in pharmaceutical
development, the FDA launched the quality by design (QbD) initiative. Within QbD, the …

The worldwide shared definition of “optimal design” refers to the cheapest and simplest
design able to perform the required job; most of the time this definition is strictly related to …

A framework for the integration of planning and scheduling using data-driven methodologies
is proposed. First, the constraints at the planning level related to the scheduling problem are …

With the raw material and energy transition to biomass‐based feedstocks and renewable
energy sources, flexible chemical reactor designs which are capable of converting more …

This paper addresses impacts of three synthesis schemes, ie the direct scheme, the indirect
scheme and the hybrid scheme on the economic and operational performances of hydrogen …

We present a computational framework for analyzing and quantifying system flexibility. Our
framework incorporates new features that include: general uncertainty characterizations that …

Flexibility index is an effective indicator for characterizing the operational flexibility of a
process design model. In this work, the concept of δ‐space projection is proposed and …

This paper presents a flexible heat exchanger network (HEN) synthesis methodology to
cope with (i) the fluctuations of uncertain process parameters and (ii) the gradually …