Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

Characterization of tumor metabolism with spatial information contributes to our
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …

Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

Background Current methods to identify, classify, and predict tumor behavior mostly rely on
histology, immunohistochemistry, and molecular determinants. However, better predictive …

There are numerous reports demonstrating the heterogeneous spatial distributions of lipids
throughout biology using mass spectrometry imaging (MSI). However, despite these and the …

Rapid, sensitive, precise and accurate analysis of samples in their native in vivo
environment is critical to better decipher physiological and physiopathological mechanisms …

Direct sampling mass spectrometry (MS) has been advancing aggressively, showing
immense potential in translating MS into the clinical field. Unlike traditional MS analysis …

Aberrant lipid accumulation and marked changes in cellular lipid profiles are related to
breast cancer metabolism and disease progression. In vitro, these phenomena are primarily …

Rapid evaporative ionization mass spectrometry (REIMS) is a highly versatile technique
allowing the sampling of a range of biological solid or liquid samples with no sample …