Objective HLA alleles affect susceptibility to more than 100 diseases, but the mechanisms
that account for these genotype–disease associations are largely unknown. HLA alleles …

Background Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS).
However, the mechanism underlying enhanced Th17 cell accumulation in AS remains …

The interaction of dendritic cells (DCs) with the human microbiome, with distorted handling
of the microbiota or its products via the direct effect of HLA B27, probably represents the …

Blood values of calcium (Ca), inorganic phosphorus (IP), and alkaline phosphatase activity
(ALP) are valuable indicators for mineral status and bone mineralization. The mineral …

Various studies have investigated the serum sclerostin and bone morphogenetic protein-2
(BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent …

Spondyloarthritis (SpA) comprises a group of diseases characterized by axial, entheseal,
and peripheral joint inflammation in the setting of overlapping nonmusculoskeletal …

Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor)
encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is …

The mechanisms underlying new bone formation in individuals with axial spondyloarthritis
(axSpA) remain unclear; however, low levels of sclerostin (SOST) may be associated with …

Abstract Mathioudaki, A. 2019. Complex disease genetics: Utilising targeted sequencing
and homogeneous ancestry. Digital Comprehensive Summaries of Uppsala Dissertations …

Background. I meccanismi di neoformazione ossea ed il link patogenetico che lega
quest'ultima all'infiammazione e alla attività di malattia nelle spondiloartriti assiali (axSpA) …