Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Microbiome-wide association studies on large population cohorts have highlighted
associations between the gut microbiome and complex traits, including type 2 diabetes …

More than one in three adults worldwide is either overweight or obese. Epidemiological
studies indicate that the location and distribution of excess fat, rather than general adiposity …

The prevalence of cardiometabolic disorders in both women and men has increased
worldwide and is linked to a rise in obesity and obesity-associated associated clustering of …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Functional genomics data has the potential to increase GWAS power by identifying SNPs
that have a higher prior probability of association. Here, we introduce a method that …

Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …

Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …