Insulin resistance (IR) is a pathological condition strongly associated with obesity. However,
corticosteroids or growth hormone therapy and genetic diseases may affect insulin …

Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes,
and cardiovascular disease. These diseases are associated with accumulation of lipids in …

Background and aims Obesity and insulin levels can influence each other by metabolism.
However, their temporal sequences and influence on hypertension are generally unknown …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Heart failure with preserved ejection fraction (HFpEF) is a complex, heterogeneous
syndrome in need of improved classification given its high morbidity and mortality and few …

Background Obesity is a precursor to heart failure with preserved ejection fraction.
Biomarkers that identify preclinical metabolic heart disease (MHD) in young obese patients …

Cardiac metabolism affects systemic energetic balance. Previously, we showed that Krüppel-
like factor (KLF)-5 regulates cardiomyocyte PPARα and fatty acid oxidation-related gene …

Abstract Aim Natriuretic peptides (NPs) have emerged as important regulators of lipid
metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 …

Аннотация Основным клиническим проявлением сердечной недостаточности с
сохраненной ФВ (СНсФВ) является плохая переносимость физической нагрузки …

Background. The diagnostic and prognostic role of N‐terminal pro‐B‐type natriuretic peptide
(NT‐proBNP) in heart failure is well established. However, additional factors may influence …