The gut-bone axis: how bacterial metabolites bridge the distance

MM Zaiss, RM Jones, G Schett… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The gut microbiome is a key regulator of bone health that affects postnatal skeletal
development and skeletal involution. Alterations in microbiota composition and host …

Dietary amino acids and the gut‐microbiome‐immune axis: physiological metabolism and therapeutic prospects

N Ma, X Ma - Comprehensive Reviews in Food Science and …, 2019 - Wiley Online Library
Dietary amino acids (AAs) are not only absorbed and metabolized by enterocytes but also
available to the microbiota in the gut in mammals. In addition to serving as the materials for …

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut

TC Fung, HE Vuong, CDG Luna, GN Pronovost… - Nature …, 2019 - nature.com
The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the
intestinal epithelium and lumen,,,–. However, whether 5-HT plays a functional role in …

Gut microbiota alterations associated with reduced bone mineral density in older adults

M Das, O Cronin, DM Keohane, EM Cormac… - …, 2019 - academic.oup.com
Objective To investigate compositional differences in the gut microbiota associated with
bone homeostasis and fractures in a cohort of older adults. Methods Faecal microbiota …

Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption

JD Schepper, FL Collins, ND Rios‐Arce… - Journal of Bone and …, 2019 - academic.oup.com
Antibiotic treatment, commonly prescribed for bacterial infections, depletes and
subsequently causes long‐term alterations in intestinal microbiota composition. Knowing the …

The gut microbiota is a major regulator of androgen metabolism in intestinal contents

H Colldén, A Landin, V Wallenius… - American Journal …, 2019 - journals.physiology.org
Androgens exert important effects both in androgen-responsive tissues and in the intestinal
tract. To determine the impact of the gut microbiota (GM) on intestinal androgen metabolism …

Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled …

PA Jansson, D Curiac, IL Ahrén, F Hansson… - The Lancet …, 2019 - thelancet.com
Background Postmenopausal bone loss in the spine is associated with an increased risk of
vertebral fractures. Certain probiotic treatment protects rodents from ovariectomy-induced …

Gut microbiota composition and bone mineral loss—epidemiologic evidence from individuals in Wuhan, China

C Li, Q Huang, R Yang, Y Dai, Y Zeng, L Tao… - Osteoporosis …, 2019 - Springer
We explored the association between gut microbiota composition and bone mineral loss in
Chinese elderly people by high-throughput 16S ribosomal RNA (rRNA) gene sequencing …

The relationship between the serotonin metabolism, gut-microbiota and the gut-brain axis

C Stasi, S Sadalla, S Milani - Current drug metabolism, 2019 - ingentaconnect.com
Background: Serotonin (5-HT) has a pleiotropic function in gastrointestinal, neurological/
psychiatric and liver diseases. The aim of this review was to elucidate whether the gut …

Bone diseases in patients with chronic liver disease

HM Jeong, DJ Kim - International journal of molecular sciences, 2019 - mdpi.com
Osteoporosis is a frequently observed complication in patients with chronic liver disease,
particularly liver cirrhosis and cholestatic liver diseases. In addition, osteoporosis is critical in …