Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells

J Hasselmann, M Blurton‐Jones - Glia, 2020 - Wiley Online Library
Recent advances in the generation of microglia from human induced pluripotent stem cells
(iPSCs) have provided exciting new approaches to examine and decipher the biology of …

Innate and adaptive immune responses in Parkinson's disease

AM Schonhoff, GP Williams, ZD Wallen… - Progress in brain …, 2020 - Elsevier
Parkinson's disease (PD) has classically been defined as a movement disorder, in which
motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and …

The role of natural killer cells in Parkinson's disease

RH Earls, JK Lee - Experimental & Molecular Medicine, 2020 - nature.com
Numerous lines of evidence indicate an association between sustained inflammation and
Parkinson's disease, but whether increased inflammation is a cause or consequence of …

Chemically induced models of Parkinson's disease: history and perspectives for the involvement of ferroptosis

S Wen, T Aki, K Unuma, K Uemura - Frontiers in cellular …, 2020 - frontiersin.org
Ferroptosis is a newly discovered form of necrotic cell death characterized by its
dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently …

Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications

E Angelopoulou, YN Paudel, MF Shaikh… - Pharmacological …, 2020 - Elsevier
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD) with
the dysregulation of microglial activity being tightly linked to dopaminergic degeneration …

Microglial phenotypes and their relationship to the cannabinoid system: therapeutic implications for Parkinson's disease

R Kelly, V Joers, MG Tansey, DP McKernan, E Dowd - Molecules, 2020 - mdpi.com
Parkinson's disease is a neurodegenerative disorder, the motor symptoms of which are
associated classically with Lewy body formation and nigrostriatal degeneration …

The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications

KZ Kuter, MA Cenci, AR Carta - Progress in Brain Research, 2020 - Elsevier
Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been
recognized to also affect the functions and integrity of microglia and astroglia, two cell …

Воспалительное старение как основа возраст-ассоциированной патологии

ОВ Артемьева, ЛВ Ганковская - Медицинская иммунология, 2020 - cyberleninka.ru
Старение представляет собой одно из самых сложных биологических явлений,
которое затрагивает все физиологические системы организма человека, в том числе …

[HTML][HTML] Inflammaging as the basis of age-associated diseases

OV Artemyeva, LV Gankovskaya - Medical Immunology (Russia), 2020 - mimmun.ru
Aging is one of the most complex biological phenomena that affects all human physiological
systems, including the immune system. Immunosenescence is understood as structural and …

Neuroinflammation in Parkinson's Disease: role in neuropathology and L-DOPA-induced motor complications.

L Boi - 2020 - iris.unica.it
Parkinson Disease (PD) is a neurodegenerative disorder characterized by the progressive
dopaminergic loss in the Substantia Nigra (SN) and the presence of intracellular Lewy …