Most complex diseases involve genetic and environmental risk factors, engage multiple cells
and tissues, and follow a polygenic or omnigenic model depicting numerous genes …

Abstract Purpose of Review Obesity is a significant international public health epidemic with
major downstream consequences on morbidity and mortality. While lifestyle factors …

A major challenge in modern biology is to understand how naturally occurring variation in
DNA sequences affects complex organismal traits through networks of intermediate …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Substantial evidence implicates crosstalk between metabolic tissues and the immune
system in the inception and progression of obesity. However, molecular regulators that …

Excessive fat deposition can cause chicken health problem, and affect production efficiency
by causing great economic losses to the industry. However, the molecular underpinnings of …

Network approaches have become pervasive in many research fields. They allow for a more
comprehensive understanding of complex relationships between entities as well as their …

The cumulative of genes carrying mutations is vital for the establishment and development of
cancer. However, this driver gene exploring research line has selected and used types of …

Animals vary in their rates of energy expenditure for self-maintenance (standard metabolic
rate [SMR]). Yet we still lack a thorough understanding of the determinants of SMR …

Background Transcriptome analysis of abdominal subcutaneous white adipose tissue
(sWAT) has identified important obesity-associated disturbances. However, the relation …