Human embryonic stem cells (hESCs) possess the potential of long-term self-renewal and
three primary germ layers differentiation, and thus hESCs are expected to have broad …

The development of novel 3D tissue culture systems has enabled the in vitro study of in vivo
processes, thereby overcoming many of the limitations of previous 2D tissue culture …

Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state.
However, the re-organization of 3D chromatin structure in this process remains poorly …

Multipotent ΔNp63-positive cells maintain all epithelial cell lineages of the embryonic and
adult salivary gland (SG). However, the molecular mechanisms by which ΔNp63 regulates …

Background Paternal obesity has been associated with reduced live birth rates. It could lead
to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms …

Liver organogenesis and development are composed of a series of complex, well-
orchestrated events. Identifying key factors and pathways governing liver development will …

Clinical evidence suggests that doxorubicin (DOX), as a chemotherapeutic drug, can induce
severe bone damage in cancer patients. However, the effect of DOX on osteoporosis has not …

STUDY QUESTION Does oocyte maturation under lipolytic conditions have detrimental carry-
over effects on post-hatching embryo development of good-quality blastocysts after transfer …

Simple Summary Melanoma cells reside in a complex stromal microenvironment, which is a
critical component of disease onset and progression. Mesenchymal or fibroblastic cell type …

Background Arctium lappa L. root (burdock root) has long been recommended for the
treatment of different diseases in traditional Chinese medicine. Burdock root possesses anti …