Evolution and genetic diversity of primate cytomegaloviruses
Cytomegaloviruses (CMVs) infect many mammals, including humans and non–human
primates (NHPs). Human cytomegalovirus (HCMV) is an important opportunistic pathogen …
primates (NHPs). Human cytomegalovirus (HCMV) is an important opportunistic pathogen …
Polymorphisms in human cytomegalovirus glycoprotein O (gO) exert epistatic influences on cell-free and cell-to-cell spread and antibody neutralization on gH …
LZ Day, C Stegmann, EP Schultz, JM Lanchy… - Journal of …, 2020 - Am Soc Microbiol
Human cytomegalovirus (HCMV) glycoproteins H and L (gH/gL) can be bound by either gO
or the UL128 to UL131 proteins (referred to here as UL128-131) to form complexes that …
or the UL128 to UL131 proteins (referred to here as UL128-131) to form complexes that …
Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double-stranded DNA viruses
Our knowledge of the diversity and frequency of genomic structural variation segregating in
populations of large double-stranded (ds) DNA viruses is limited. Here, we sequenced the …
populations of large double-stranded (ds) DNA viruses is limited. Here, we sequenced the …
Specialization for cell-free or cell-to-cell spread of BAC-cloned human cytomegalovirus strains is determined by factors beyond the UL128-131 and RL13 loci
EP Schultz, JM Lanchy, LZ Day, Q Yu… - Journal of …, 2020 - Am Soc Microbiol
It is widely held that clinical isolates of human cytomegalovirus (HCMV) are highly cell
associated, and mutations affecting the UL128-131 and RL13 loci that arise in culture lead …
associated, and mutations affecting the UL128-131 and RL13 loci that arise in culture lead …
Past and ongoing adaptation of human cytomegalovirus to its host
Cytomegaloviruses (order Herpesvirales) display remarkable species-specificity as a result
of long-term co-evolution with their mammalian hosts. Human cytomegalovirus (HCMV) is …
of long-term co-evolution with their mammalian hosts. Human cytomegalovirus (HCMV) is …
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict
species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal …
species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal …
Whole-genome approach to assessing human cytomegalovirus dynamics in transplant patients undergoing antiviral therapy
Human cytomegalovirus (HCMV) is the most frequent cause of opportunistic viral infection
following transplantation. Viral factors of potential clinical importance include the selection of …
following transplantation. Viral factors of potential clinical importance include the selection of …
Cytomegalovirus genetic diversity following primary infection
SA Ross, P Pati, TL Jensen, JB Goll… - The Journal of …, 2020 - academic.oup.com
Background Infection with multiple cytomegalovirus (CMV) strains (mixed infection) was
reported in a variety of hosts. As the virus genetic diversity in primary CMV infection and the …
reported in a variety of hosts. As the virus genetic diversity in primary CMV infection and the …
Influence of human cytomegalovirus glycoprotein O polymorphism on the inhibitory effect of soluble forms of trimer-and pentamer-specific entry receptors
N Brait, T Stögerer, J Kalser, B Adler, I Kunz… - Journal of …, 2020 - Am Soc Microbiol
Human cytomegalovirus (HCMV) envelope glycoprotein complexes, gH/gL/gO trimer and
gH/gL/UL128-131 pentamer, are important for cell-free HCMV entry. While soluble NRP2-Fc …
gH/gL/UL128-131 pentamer, are important for cell-free HCMV entry. While soluble NRP2-Fc …
Human cytomegalovirus long non-coding RNA1. 2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation
Long non-coding RNAs (lncRNAs) are transcripts of> 200 nucleotides that are not translated
into functional proteins. Cellular lncRNAs have been shown to act as regulators by …
into functional proteins. Cellular lncRNAs have been shown to act as regulators by …